Dicarboxylic acids and derivatives
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-10mM/1mL
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Medchemexpress LLC Lauroyl-L-carnitine chloride | 6919-91-1 | 98.1% | 1 ML
Lauroyl-L-carnitine chloride is an orally active metabolite that significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis. This product is for research use only.
- Orally active metabolite
- Reverses decrease in IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes of TNBS mice
TARGETMOL CHEMICALS INC GLYH-101 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. purity: 98%
TARGETMOL CHEMICALS INC CUDC-101 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CUDC-101 is a potent inhibitor of HDAC EGFR and HER2 with IC50s of 4.4 2.4 and 15.7 nM respectively. purity: 99%
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | 574.66 | C28H35FN4O6S | 10 MG
VH 101, acid is a functionalized von Hippel-Lindau (VHL) E3 ligase ligand developed for PROTAC research and conjugation chemistry. The molecule includes an E3 ligase recognition motif and an alkyl linker terminating in a primary amine, facilitating attachment to target protein ligands.
- Designed for use as a VHL E3 ligase ligand in PROTAC development.
- Alkyl linker with terminal amine enables straightforward conjugation chemistry.
- High reported purity suitable for research applications.
- Supplied in small research-scale quantities for synthetic work and assay testing.
eMolecules Diethyl 2,2-thiodiacetate | Ambeed | 925-47-3 | MFCD00087932 | 206.260 | C8H14O4S | 98.000 | CCOC(=O)CSCC(=O)OCC | 5g | 600849984
Diethyl 2,2-thiodiacetate | Ambeed | 925-47-3 | MFCD00087932 | 206.260 | C8H14O4S | 98.000 | CCOC(=O)CSCC(=O)OCC | 5g | 600849984
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | 98.1% | 1 MG
Lauroyl-L-carnitine chloride is an orally active metabolite that significantly reverses the decrease in its target gene IL-10, alleviating Crohn's-like colitis. It demonstrates anti-inflammatory effects and improves both systemic and local phenotypes in TNBS mice.
- Orally active metabolite
- Reverses decrease in target gene IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes in TNBS mice
Medchemexpress LLC Sodium lauroyl glutamate | 29923-31-7 | 95.8% | 5 G
Sodium lauroyl glutamate is an anionic amino acid surfactant with potential for irritant contact dermatitis and possible anti-irritating potential in surfactant mixtures on human skin.
- Anionic amino acid surfactant
- Potential for irritant contact dermatitis
- Possible anti-irritating potential
Apexbio Technology LLC CAL-101 (Idelalisib, GS-1101) 870281-82-6 100mg
CAL-101 (Idelalisib GS-1101 CAS 870281-82-6) is a selective inhibitor targeting the p110 isoform of phosphatidylinositol 3-kinase (PI3K) an enzyme involved in signaling pathways critical for proliferation and survival of malignant B cells By inhibiting PI3K p110 CAL-101 reduces PI3K-mediated phosphorylation of Akt and other downstream factors leading to enhanced PARP cleavage and caspase activation ultimately inducing apoptosis in malignant B cells CAL-101 has been demonstrated to counteract survival signals initiated by molecules such as CD40 ligand (CD40L) TNF- and fibronectin This agent is valuable in investigating B-cell malignancies
Medchemexpress LLC Pigment Yellow 101 | 2387-03-3 | 98.1% | 5 MG
Pigment Yellow 101 is a yellow bis-azomethine pigment with excitation/emission at 411 nm/512 nm. It exhibits solid-state fluorescence and is available as a commercial colorant. This product is for research use only and not sold to patients.
- Yellow bis-azomethine pigment
- Exhibits solid-state fluorescence
- Excitation/emission: 411 nm/512 nm
- Available as a commercial colorant
Medchemexpress LLC 1,2-Dilauroyl-sn-glycerol | 60562-15-4 | 98.0% | 25 MG
1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol that may participate in second messenger signal transduction. It is intended for research use only and is not sold to patients.
- Potential role in second messenger signal transduction.
- Crucial intracellular signaling molecules involved in regulating various physiological processes.
- Specifically designated for research purposes.